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Fig. 1 | BMC Cancer

Fig. 1

From: Molecular targeted photoimmunotherapy for HER2-positive human gastric cancer in combination with chemotherapy results in improved treatment outcomes through different cytotoxic mechanisms

Fig. 1

In vitro human epidermal growth factor receptor 2 (HER2) expression in human gastric cancer cells. a, b Flow cytometry revealed strong HER2-specific signals in NCI-N87 cells and very weak signals in MKN-45 cells. Specific binding of trastuzumab-IR700 was demonstrated by excess trastuzumab blocking. c, d, e Fluorescence microscopy showed HER2-specific IR700 localization in NCI-N87 cells. Conversely, IR700 fluorescence was not detected in MKN-45 cells or in NCI-N87 cells pre-treated with an excess volume of trastuzumab. Cellular swelling and bleb formation were rapidly induced after excitation light in NCI-N87 cells but not in MKN-45 cells (lower right). Scale bar, 50 μm. DIC: differential interference contrast, NIR: near-infrared

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BMC Cancer

ISSN: 1471-2407

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