Table 1 Establishment of SN-38 resistant cell lines
From: Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines
Cell Lines | SN-38 Dose | Final SN-38 concentration | IC50 Values (μM) | RR | |
|---|---|---|---|---|---|
Resistant cell lines | DMSO control | ||||
MDAacq | Stepwise (3.6nM-68.2nM) | 68.2nM | 40.2 ± 4.0 | 5.6 ± 0.9 | 7.2 |
MCF-7acq | Stepwise (3.0nM-36nM) | 36nM | 33.6 ± 3.0 | 3.7 ± 0.5 | 9.1 |
MDAde novo | Constant (24nM) | 24nM | 66.8 ± 16.2 | 0.7 ± 0.5 | 95.4 |
MCF-7de novo | Constant (12nM) | 12nM | 31.9 ± 0.6 | 2.3 ± 0.9 | 13.9 |