Fig. 4
From: Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines
Inhibition of the BCRP efflux pump in SN-38 resistant cell lines in comparison to their controls in MTT assay. Cells were exposed to their corresponding final SN-38 concentration with or without Ko143 (5 μM) for 72 h. Triplicate wells were analyzed, and data shown is mean ± s.d. of a representative experiment in percent of untreated cells (controls), n = 3. The p-values between SN-38 treated and SN-38 + 5 μM inhibitor were all below 0.05 (the p-values for MDAacq, MCF-7acq, MDAde novo and MCF-7de novo were 9.6E-5, 0.01, 7.2E-5 and 0.0001, respectively)