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Table 3 Incidence of AEs during PCT or PCRT according to CTCAE and Clavien-Dindo gradesa

From: Correlation analyses between pre- and post-operative adverse events in gastric cancer patients receiving preoperative treatment and gastrectomy

  CD0 group (n = 61) CD1/2 group (n = 44) CD3/4 group (n = 10) Total (n = 115) P Value
Anemia      0.099
     Grade 0 6 (5.2) 6 (5.2) 0 (0.0) 12 (10.4)  
     Grade 1/2 48 (41.7) 27 (23.5) 6 (5.2) 81 (70.4)  
     Grade 3/4 7 (6.1) 11 (9.6) 4 (3.5) 22 (19.1)  
Leukopenia     0.326
     Grade 0 24 (20.9) 9 (7.8) 4 (3.5) 37 (32.2)  
     Grade 1/2 21 (18.3) 21 (18.3) 3 (2.6) 45 (39.1)  
     Grade 3/4 16 (13.9) 14 (12.2) 3 (2.6) 33 (28.7)  
Neutropenia     0.244
     Grade 0 16 (13.9) 4 (3.5) 3 (2.6) 23 (20.0)  
     Grade 1/2 19 (16.5) 16 (13.9) 3 (2.6) 38 (33.0)  
     Grade 3/4 26 (22.6) 24 (20.9) 4 (3.5) 54 (47.0)  
Febrile neutropenia     0.829
     Grade 0 49 (42.6) 35 (30.4) 9 (7.8) 93 (80.9)  
     Grade 3/4 12 (10.4) 9 (7.8) 1 (0.9) 22 (19.1)  
Lymphocytopenia     0.748
     Grade 0 10 (8.7) 9 (7.8) 2 (1.7) 21 (18.3)  
     Grade 1/2 41 (35.7) 29 (25.2) 5 (4.3) 75 (65.2)  
     Grade 3/4 10 (8.7) 6 (5.2) 3 (2.6) 19 (16.5)  
Thrombocytopenia     0.798
     Grade 0 39 (33.9) 26 (22.6) 8 (7.0) 73 (63.5)  
     Grade 1/2 19 (16.5) 16 (13.9) 2 (1.7) 37 (32.2)  
     Grade 3/4 3 (2.6) 2 (1.7) 0 (0.0) 5 (4.3)  
Increased ALT/AST   0.718
     Grade 0 34 (29.6) 28 (24.3) 6 (5.2) 68 (59.1)  
     Grade 1/2 27 (23.5) 16 (13.9) 4 (3.5) 47 (40.9)  
Increased Scr     1.000
     Grade 0 58 (50.4) 41 (35.7) 9 (7.8) 108 (93.9)  
     Grade 1/2 3 (2.6) 3 (2.6) 1 (0.9) 7 (6.1)  
Total AEs   0.138
     Grade 0 0 (0.0) 1 (0.9) 0 (0.0) 1 (0.9)  
     Grade 1/2 29 (25.2) 11 (9.6) 3 (2.6) 43 (37.4)  
     Grade 3/4 32 (27.8) 32 (27.8) 7 (6.1) 71 (61.7)  
  1. AEs adverse events, ALT alanine transaminase, AST aspartate transaminase, CTCAE common terminology criteria for adverse events, PCRT preoperative chemoradiotherapy, PCT preoperative chemotherapy, Scr serum creatinine
  2. aData are presented as number (incidence)