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Table 5 Association values between genotypes and metabolizer phenotypes

From: A pharmacogenetic pilot study reveals MTHFR, DRD3, and MDR1 polymorphisms as biomarker candidates for slow atorvastatin metabolizers

Association between genotype combinations and metabolizer phenotypes

Clusters

Phenotypes

OR (95 % CI)

P-Value

Pc Value

A, B, C

Rapid, Normal, Slow

-

1 × 10−3**

3.1 × 10−3**

C, A + B

Slow, Normal + Rapid

4.00 (1.39–11.49)*

3.83 × 10−4**

1 × 10−3**

D, E, F

Rapid, Normal, Slow

-

6.6 × 10−5**

1.6 × 10−3**

F, D + E

Slow, Normal + Rapid

4.53 (1.62–12.68)*

7 × 10−6**

2.9 × 10−5**

  1. OR odds ratio, CI confidence interval, Pc P-values adjusted by using Bonferroni’s correction for multiple comparisons, − = Not calculated, ** = P ≤ 0.05. Clusters are explained in the main text