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Table 5 Association values between genotypes and metabolizer phenotypes

From: A pharmacogenetic pilot study reveals MTHFR, DRD3, and MDR1 polymorphisms as biomarker candidates for slow atorvastatin metabolizers

Association between genotype combinations and metabolizer phenotypes
Clusters Phenotypes OR (95 % CI) P-Value Pc Value
A, B, C Rapid, Normal, Slow - 1 × 10−3** 3.1 × 10−3**
C, A + B Slow, Normal + Rapid 4.00 (1.39–11.49)* 3.83 × 10−4** 1 × 10−3**
D, E, F Rapid, Normal, Slow - 6.6 × 10−5** 1.6 × 10−3**
F, D + E Slow, Normal + Rapid 4.53 (1.62–12.68)* 7 × 10−6** 2.9 × 10−5**
  1. OR odds ratio, CI confidence interval, Pc P-values adjusted by using Bonferroni’s correction for multiple comparisons, − = Not calculated, ** = P ≤ 0.05. Clusters are explained in the main text