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Table 2 Pharmacokinetic parameters according to metabolizer phenotype

From: A pharmacogenetic pilot study reveals MTHFR, DRD3, and MDR1 polymorphisms as biomarker candidates for slow atorvastatin metabolizers

  All subjects Phenotype
Parameters   Slow Normal Rapid
N 60 18 25 17
Cmax (ng/mL) 41.44 ± 23.35 75.39 ± 15.74* 40.48 ± 6.37* 22.11 ± 8.15*
AUC0-t (ng/mL*h) 141.88 ± 86.78 218.14 ± 101.90* 152.69 ± 48.83* 80.78 ± 27.24*
AUC0-∞ (ng/mL*h) 157.12 ± 87.24 231.55 ± 100.02* 166.35 ± 55.59* 95.81 ± 28.38*
Cl/F (L/h) 509.20 ± 265.57 345.49 ± 119.94* 480.93 ± 152.07* 834.97 ± 249.52*
T1/2 (h) 9.81 ± 6.58 9.64 ± 6.18 10.76 ± 7.54 8.71 ± 5.43
Ke 0.071 ± 0.035 0.072 ± 0.041* 0.064 ± 0.030* *0.080 ± 0.035
  1. Data shown as geometric mean (± Standard Deviation)
  2. *statistically significant (P ≤ 0.016)