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Fig. 4 | BMC Cancer

Fig. 4

From: Mutations in TP53 increase the risk of SOX2 copy number alterations and silencing of TP53 reduces SOX2 expression in non-small cell lung cancer

Fig. 4

Effects of silencing of the TP53 and SOX2 genes on the expression of SOX2, TP53 and hsa-miRNA-145-5p in pulmonary adenocarcinoma A427 cells. a TP53 was silenced using siRNA technology and expression of SOX2 and hsa-miR-145-5p was analyzed by qPCR. Bars indicate mean ± SE, n = 9 and n = 12 for SOX2 and hsa-miR-145-5p, respectively. b SOX2 was silenced using siRNA technology and expression of TP53 was analyzed by qPCR. Bars indicate mean ± SE, n = 9. ***indicating p < 0.001 and **indicating p < 0.01 was obtained from nonparametric Mann–Whitney test

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