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Fig. 1 | BMC Cancer

Fig. 1

From: Mutations in TP53 increase the risk of SOX2 copy number alterations and silencing of TP53 reduces SOX2 expression in non-small cell lung cancer

Fig. 1

SOX2 copy number alterations in lung tumors (n = 244). a Percentage of SOX2 gene amplifications and deletions in lung tumors and non-tumorous tissues. b Distribution of SOX2 copy numbers in lung tumors. More than 2.5 copy numbers were defined as amplifications, whereas less than 1.5 copy numbers were defined as deletions. c Distribution of copy number alterations between NSCLC of different histology. AD: adenocarcinoma, SQ: squamous cell carcinoma and LC: large cell carcinoma. d Correlation between the relative genomic SOX2 levels and its mRNA expression. r = 0.875, p < 0.001 was obtained from Spearman's Rank-Order Correlation (n = 30)

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