Skip to main content
Fig. 2 | BMC Cancer

Fig. 2

From: Novel c-Met inhibitor suppresses the growth of c-Met-addicted gastric cancer cells

Fig. 2

c-Met inhibitors are sensitive only to c-Met over-expressed cell lines. a The lysates of 18 gastric cancer cell lines were prepared for immunoblot with antibodies of c-Met and phospho c-Met (pY1234/1235). For cytotoxic IC50 measurement, cells were seeded on 96 well plates and were treated with chemicals for 72 h. After 72 h, WST-1 reagent was added to each well and absorbance at 450 nm was read with microplate reader (Molecular Device). IC50 was calculated with Prizm software program. The numbers indicate the cytotoxic micro molar IC50 (μM) of each compound. b-c The viability curves of each gastric cancer cell line treated with KRC-00509 (b) or KRC-00715 (c)

Back to article page