Skip to main content

Table 1 PAK1 knock-down (KD) inhibits proliferation and increases gemcitabine sensitivity

From: FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine

 

Growth rate (%/h)

Gemcitabine IC50 (nM)

PANC-1

MiaPaCa-2

PANC-1

MiaPaCa-2

NC1

2.4

2.9

26 ± 2

29 ± 1

NC2

2.6

2.7

39 ± 1

28 ± 1

KD1

1.9 *

2.0 **

20 ± 2 **

26 ± 1 *

KD2

2.1 *

2.1 **

21 ± 2 *

25 ± 2 *

  1. NC1 and NC2 indicate PANC-1 NC clones NC1 and NC2; and MiaPaCa-2 NC clones NC2 and NC8 respectively. KD1 and KD2 indicate PANC-1 KD clones 2.05 and 2.10; and MiaPaCa-2 KD clones 3.09 and 3.12 respectively. * p < 0.05; ** p < 0.01, compared to either NC clone (only the higher p value of the two is presented)
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us