Fig. 1

Representitive examples of FoxC2 and E-cadherin expression in NSCLC and normal lung tissue. Immunoreactivity of FoxC2 was mainly detected in the cytosol and nuclei, while E-cadherin expression was primarily membranous. High level of FoxC2 expression was correlated with impaired E-cadherin expression. a and c preserved expression of E-cadherin in normal tissue; (b and d) weak expression of FoxC2 in normal tissue; (e and g) preserved expression of E-cadherin in NSCLC; (f and h) low expression of FoxC2 in NSCLC; (i and k) impaired expression of E-cadherin in NSCLC; (j and l) high expression of FoxC2 in NSCLC