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Fig. 2 | BMC Cancer

Fig. 2

From: Constitutive expression of AhR and BRCA-1 promoter CpG hypermethylation as biomarkers of ERα-negative breast tumorigenesis

Fig. 2

Brca-1 promoter methylation is increased in DMBA-induced rat mammary adjacent tissues and tumors. a Cycle number and no-template control (NTC) for amplification of rat Brca-1 promoter with U- and M-specific primers. MW, molecular weight markers; b Methylation status of Brca-1 promoter in control mammary gland, and in adjacent mammary tissues and tumors of four representative (1-4) animals; C) Quantitation from genomic DNA of Brca-1 promoter methylation status (M/U ratio) compared to control from 8 animals/group (n = 8). Means ± SEM without a common letter differ (P < 0.05)

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