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Table 3 Rate of breast cancer related to meningeal carcinomatosis in patients with bone and/or brain metastasis occurrence: 5 years (column A) and 10 years (column B) after surgery

From: Meningeal carcinomatosis underdiagnosis and overestimation: incidence in a large consecutive and unselected population of breast cancer patients

  Column A: 5-year follow up Column B: 10-year follow up
MC events Patients Person-years Rate (per 100) MC events Patients Person-years Rate (per 100)
Occurrence of bone metastasisa
 No 2 1780 5434 0.037 (0.0092–0.147) 3 1898 7770 0.039 (0.012–0.12)
 Yes 1 52 84 1.19 (0.168–0.85) 3 87 177 1.69 (0.55–5.25)
     (p < 0.001)     (p < 0.001)
Occurrence of brain metastasis
 No 2 1792 5510 0.036 (0.0091–0.15) 3 1912 7929 0.038 (0.012–0.12)
 yes 1 9 7 14.36 (2.02–101.93) 3 15 18 16.58 (5.35–51.41)
     (p < 0.001)     (p < 0.001)
  1. aPatients sum up to more than 1793 (5-year follow-up) or 1915 (10-year follow-up) because bone and brain metastases are time-dependent variables; thus, a single patient who developed metastasis during the follow up contributed to both levels (yes and no) of the variable