Table 2 Rate of breast cancer-related meningeal carcinomatosis, 5Â years (column A) and 10Â years (column B) after surgery
| Â | Column A: 5-year follow upa | Column B: 10-year follow upb | ||||||
|---|---|---|---|---|---|---|---|---|
MC events | Patients | Person-years | Rate (per 10.000) | MC events | Patients | Person-years | Rate (per 10.000) | |
Patients | 3 | 1793 | 5518 | 5.44 (1.75–16.9) | 6 | 1915 | 7947 | 7.55 (3.39–16.8) |
Age at diagnosis | ||||||||
 - <50 years | 3 | 324 | 999 | 30.0 (9.69–93.1) | 6 | 338 | 1446 | 41.1 (18.6–92.4) |
 - ≥50 years | 0 | 1469 | 4519 | 0 | 0 | 1577 | 6502 | 0 |
|  |  |  |  | (p =0.002) |  |  |  | (p < 0.001) |
Treatment | ||||||||
 -Tumorectomy | 2 | 1325 | 4146 | 4.82 (1.21–19.3) | 2 | 515 | 1972 | 20.3 (7.61–54.0) |
 -Mastectomy | 1 | 468 | 1372 | 7.29 (1.03–51.7) | 4 | 1400 | 5975 | 3.34 (0.84–13.4) |
|  |  |  |  | (p =0.73) |  |  |  | (p = 0.018) |
Histological grade | ||||||||
 - G1 | 0 | 528 | 1515 | 0 | 0 | 564 | 2323 | 0 |
 - G2 | 0 | 854 | 2770 | 0 | 2 | 908 | 3799 | 5.26 (1.32–21.0) |
 - G3 | 3 | 403 | 1211 | 24.8 (7.99–76.8) | 4 | 435 | 1794 | 22.3 (8.4–59.4) |
|  |  |  |  | (p < 0.001) |  |  |  | (p = 0.007) |
Tumor size | ||||||||
 - ≤ 15 mm | 0 | 949 | 2927 | 0 | 0 | 1019 | 4280 | 0 |
 - > 15 mm | 3 | 838 | 2581 | 11.6 (3.75–36.0) | 6 | 890 | 3649 | 16.4 (7.39–36.6) |
|  |  |  |  | (p = 0.07) |  |  |  | (p = 0.008) |
Vascular invasion | ||||||||
 - No | 1 | 1204 | 3779 | 2.64 (0.37–18.8) | 1 | 1271 | 5323 | 1.88 (0.26–13.3) |
 - Yes | 2 | 574 | 1697 | 11.8 (2.95–47.1) | 5 | 626 | 2558 | 19.5 (8.13–47.0) |
|  |  |  |  | (p = 0.18) |  |  |  | (p = 0.008) |
pT stage | ||||||||
 - pT1 | 1 | 1262 | 3945 | 2.53 (0.36–18.0) | 1 | 1342 | 5683 | 1.76 (0.25–12.5) |
 - pT2 | 2 | 461 | 1394 | 14.3 (3.59–57.4) | 5 | 493 | 1984 | 25.2 (10.5–60.5) |
 - pT3-4 | 0 | 66 | 172 | 0 | 0 | 76 | 269 | 0 |
|  |  |  |  | (p = 0.30) |  |  |  | (p = 0.01) |
pN stage | ||||||||
 - Negative (including ITC/micrometastasis)/pN0 | 1 | 1273 | 3981 | 2.51 (0.35–17.8) | 1 | 1335 | 5594 | 1.79 (0.25–12.7) |
 - from 1 to 3 positive/pN1 | 1 | 319 | 1006 | 9.94 (1.40–70.6) | 2 | 338 | 1452 | 13.8 (3.44–55.1) |
 - >3 positives/pN2-pN3 | 1 | 149 | 391 | 25.6 (3.61–182) | 3 | 167 | 604 | 49.7 (16.0–154) |
|  |  |  |  | (p = 0.26) |  |  |  | (p = 0.004) |
ER status | ||||||||
 - Negative | 2 | 181 | 532 | 37.6 (9.40–150) | 3 | 190 | 776 | 38.6 (12.5–119) |
 - Positive | 1 | 1581 | 4869 | 2.05 (0.89–14.6) | 3 | 1693 | 7015 | 4.28 (1.38–13.3) |
|  |  |  |  | (p = 0.001) |  |  |  | (p = 0.001) |
PR status | ||||||||
 - Negative | 2 | 231 | 653 | 15.3 (2.16–109) | 2 | 256 | 966 | 10.4 (1.46–73.5) |
 - Positive | 1 | 1270 | 4090 | 4.89 (1.22–19.6) | 3 | 1365 | 5496 | 7.28 (2.73–19.4) |
|  |  |  |  | (p = 0.054) |  |  |  | (p = 0.19) |
Ki67 | ||||||||
 - <20 % | 0 | 1041 | 3224 | 0 | 2 | 1103 | 4600 | 4.35 (1.09–17.4) |
 - ≥20 % | 3 | 685 | 2037 | 14.7 (4.75–45.7) | 4 | 741 | 2990 | 13.4 (5.02–35.6) |
|  |  |  |  | (p = 0.03) |  |  |  | (p = 0.17) |
HER2 | ||||||||
 - Negative | 1 | 1574 | 4875 | 2.05 (0.29–14.6) | 3 | 1662 | 6867 | 4.37 (1.41–13.5) |
 - Positive | 2 | 144 | 452 | 44.2 (11.01–177) | 3 | 151 | 632 | 47.5 (15.3–147) |
|  |  |  |  | (p < 0.001) |  |  |  | (p < 0.001) |