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Table 2 Rate of breast cancer-related meningeal carcinomatosis, 5 years (column A) and 10 years (column B) after surgery

From: Meningeal carcinomatosis underdiagnosis and overestimation: incidence in a large consecutive and unselected population of breast cancer patients

  Column A: 5-year follow upa Column B: 10-year follow upb
MC events Patients Person-years Rate (per 10.000) MC events Patients Person-years Rate (per 10.000)
Patients 3 1793 5518 5.44 (1.75–16.9) 6 1915 7947 7.55 (3.39–16.8)
Age at diagnosis
 - <50 years 3 324 999 30.0 (9.69–93.1) 6 338 1446 41.1 (18.6–92.4)
 - ≥50 years 0 1469 4519 0 0 1577 6502 0
     (p =0.002)     (p < 0.001)
Treatment
 -Tumorectomy 2 1325 4146 4.82 (1.21–19.3) 2 515 1972 20.3 (7.61–54.0)
 -Mastectomy 1 468 1372 7.29 (1.03–51.7) 4 1400 5975 3.34 (0.84–13.4)
     (p =0.73)     (p = 0.018)
Histological grade
 - G1 0 528 1515 0 0 564 2323 0
 - G2 0 854 2770 0 2 908 3799 5.26 (1.32–21.0)
 - G3 3 403 1211 24.8 (7.99–76.8) 4 435 1794 22.3 (8.4–59.4)
     (p < 0.001)     (p = 0.007)
Tumor size
 - ≤ 15 mm 0 949 2927 0 0 1019 4280 0
 - > 15 mm 3 838 2581 11.6 (3.75–36.0) 6 890 3649 16.4 (7.39–36.6)
     (p = 0.07)     (p = 0.008)
Vascular invasion
 - No 1 1204 3779 2.64 (0.37–18.8) 1 1271 5323 1.88 (0.26–13.3)
 - Yes 2 574 1697 11.8 (2.95–47.1) 5 626 2558 19.5 (8.13–47.0)
     (p = 0.18)     (p = 0.008)
pT stage
 - pT1 1 1262 3945 2.53 (0.36–18.0) 1 1342 5683 1.76 (0.25–12.5)
 - pT2 2 461 1394 14.3 (3.59–57.4) 5 493 1984 25.2 (10.5–60.5)
 - pT3-4 0 66 172 0 0 76 269 0
     (p = 0.30)     (p = 0.01)
pN stage
 - Negative (including ITC/micrometastasis)/pN0 1 1273 3981 2.51 (0.35–17.8) 1 1335 5594 1.79 (0.25–12.7)
 - from 1 to 3 positive/pN1 1 319 1006 9.94 (1.40–70.6) 2 338 1452 13.8 (3.44–55.1)
 - >3 positives/pN2-pN3 1 149 391 25.6 (3.61–182) 3 167 604 49.7 (16.0–154)
     (p = 0.26)     (p = 0.004)
ER status
 - Negative 2 181 532 37.6 (9.40–150) 3 190 776 38.6 (12.5–119)
 - Positive 1 1581 4869 2.05 (0.89–14.6) 3 1693 7015 4.28 (1.38–13.3)
     (p = 0.001)     (p = 0.001)
PR status
 - Negative 2 231 653 15.3 (2.16–109) 2 256 966 10.4 (1.46–73.5)
 - Positive 1 1270 4090 4.89 (1.22–19.6) 3 1365 5496 7.28 (2.73–19.4)
     (p = 0.054)     (p = 0.19)
Ki67
 - <20 % 0 1041 3224 0 2 1103 4600 4.35 (1.09–17.4)
 - ≥20 % 3 685 2037 14.7 (4.75–45.7) 4 741 2990 13.4 (5.02–35.6)
     (p = 0.03)     (p = 0.17)
HER2
 - Negative 1 1574 4875 2.05 (0.29–14.6) 3 1662 6867 4.37 (1.41–13.5)
 - Positive 2 144 452 44.2 (11.01–177) 3 151 632 47.5 (15.3–147)
     (p < 0.001)     (p < 0.001)
  1. ITC isolated tumor cells
  2. amissing data: Grading: 8 missing; pN stage: 52 missing; tumor size: 6 missing; ER: 31 missing; PR: 292 missing; Ki67: 67 missing; Vascular invasion: 15 missing; pT stage: 4 missing; HER2: 75 missing
  3. bmissing data: Grading: 8 missing; pN stage: 75 missing; tumor size: 6 missing; ER: 32 missing; PR: 294 missing; Ki67: 71 missing; Vascular invasion: 18 missing; pT stage: 4 missing; HER2: 101 missing