Skip to main content

Table 3 Multivariate adjusted odds ratios (OR) and 95 % confidence intervals (CI) of ER-positive and ER-negative invasive breast cancer associated with caspase-8 polymorphisms

From: Novel polymorphisms in caspase-8 are associated with breast cancer risk in the California Teachers Study

SNP

ER-positive

ER-negative

Unadjusted

Adjusteda

Unadjusted

Adjusteda

OR

95 % CI

p**

ORa

95 % CI

p**

OR

95 % CI

p**

ORa

95 % CI

p**

rs12693932

1.075

0.957

1.207

 

1.090

0.970

1.220

 

1.013

0.800

1.282

 

1.010

0.800

1.290

 

rs6745051

1.072

0.955

1.203

 

1.080

0.960

1.220

 

0.994

0.784

1.259

 

0.990

0.780

1.260

 

rs3769825

1.108

0.989

1.242

 

1.130

1.010

1.270

0.035

1.107

0.876

1.398

 

1.140

0.900

1.440

 

rs11899004

1.160

0.990

1.358

 

1.170

1.000

1.380

 

1.029

0.734

1.443

 

1.030

0.730

1.460

 

rs6736233

1.364

1.096

1.697

0.005

1.360

1.090

1.710

0.006

1.180

0.740

1.882

 

1.260

0.780

2.020

 

rs1861270

1.038

0.914

1.178

 

1.070

0.940

1.210

 

1.066

0.824

1.379

 

1.110

0.860

1.450

 

rs6723097

1.123

0.999

1.262

 

1.160

1.030

1.310

0.014

1.089

0.859

1.381

 

1.150

0.900

1.460

 

rs2293554

1.137

0.915

1.413

 

1.170

0.930

1.460

 

1.162

0.747

1.806

 

1.210

0.770

1.900

 

rs1045485

1.088

0.911

1.300

 

1.060

0.890

1.270

 

0.942

0.638

1.391

 

0.940

0.630

1.400

 

rs1035140

1.025

0.916

1.147

 

1.040

0.930

1.170

 

1.028

0.815

1.297

 

1.080

0.860

1.370

 

rs700636

1.021

0.910

1.144

 

1.050

0.940

1.180

 

1.046

0.828

1.322

 

1.100

0.870

1.400

 

rs11679181

0.955

0.851

1.071

 

0.940

0.840

1.060

 

0.978

0.772

1.238

 

0.920

0.720

1.170

 
  1. aPer-allele ORs. Models were adjusted for center, age, family history, BMI, recent physical activity, alcohol consumption, and menopause/HT status
  2. **Only uncorrected p values <0.05 are listed