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Fig. 2 | BMC Cancer

Fig. 2

From: Natural killer (NK) cells inhibit systemic metastasis of glioblastoma cells and have therapeutic effects against glioblastomas in the brain

Fig. 2

NK cell inactivation provokes spontaneous lung metastasis of GBM cells in the brains of BALB/c-nude mice. a Experimental schedule illustrated. b Murine splenic NK cells were analyzed by flow cytometry. NKG2D-posive cell ratio was analyzed and compared. c, d Pathologic validation of brain (c) and metastatic lung tumors (d) in various orthotopic xenograft animal models. Immunohistochemistry against a cell proliferation marker (Ki-67) was performed. e Immunohistochemistry against human specific cytoplasmic antigen (STEM-121) and GBM specific markers (GFAP, Nestin and SOX2) in metastatic lung tumors. f Human-specific cytoplasmic antigen (STEM-121) was co-localized with GBM specific markers (GFAP or Nestin)

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BMC Cancer

ISSN: 1471-2407

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