Table 2 Association between NETO2 expression and clinicopathologic characteristics of CRC patients in the study cohort
Characteristics | No. of patients (%) | NETO2 expression | |||
|---|---|---|---|---|---|
Low (%) | High (%) | P value a | |||
(n = 292) | (n = 115) | (n = 177) | |||
Age (years) | 0.864 | ||||
<60 | 88 (30.1) | 34 (29.6) | 54 (30.5) | ||
≥60 | 204 (69.9) | 81 (70.4) | 123 (69.5) | ||
Sex | 0.860 | ||||
Female | 111 (38.0) | 43 (37.4) | 68 (38.4) | ||
Male | 181 (62.0) | 72 (62.6) | 109 (61.6) | ||
Tumor location | 0.227 | ||||
Right colon | 88 (30.1) | 31 (27.0) | 37 (20.9) | ||
Left colon | 71 (24.4) | 34 (29.5) | 57 (32.2) | ||
Rectum | 133 (45.5) | 50 (43.5) | 83 (46.9) | ||
Differentiation grade | 0.013 | ||||
Well | 20 (6.8) | 12 (10.4) | 8 (4.5) | ||
Moderate | 222 (76.0) | 91 (79.2) | 131 (74.0) | ||
Poor | 50 (17.2) | 12 (10.4) | 38 (21.5) | ||
Tumor size (cm) | 0.446 | ||||
<5 | 114 (39.0) | 48 (41.7) | 66 (37.3) | ||
≥5 | 178 (61.0) | 67 (58.3) | 111 (62.7) | ||
Local invasion | 0.049 | ||||
T1-T2 | 48 (16.4) | 25 (21.7) | 23 (13.0) | ||
T3-T4 | 244 (83.6) | 90 (78.3) | 154 (87.0) | ||
Lymph node metastasis | 0.009 | ||||
N0 | 164 (56.2) | 74 (64.3) | 90 (50.8) | ||
N1 | 101 (34.6) | 37 (32.2) | 64 (36.2) | ||
N2 | 27 (9.2) | 4 (3.5) | 23 (13.0) | ||
TNM stage | 0.041 | ||||
I | 40 (13.7) | 21 (18.3) | 19 (10.7) | ||
II | 124 (42.5) | 53 (46.1) | 71 (40.1) | ||
III | 128 (43.8) | 41 (35.6) | 87 (49.2) | ||
No. of examined lymph nodes | 0.655 | ||||
<12 | 152 (52.1) | 58 (50.4) | 94 (53.1) | ||
≥12 | 140 (47.9) | 57 (49.6) | 83 (46.9) | ||
Bowel obstruction/perforation | 0.537 | ||||
No | 282 (96.6) | 112 (97.4) | 170 (96.0) | ||
Yes | 10 (3.4) | 3 (2.6) | 7 (4.0) | ||
Adjuvant chemotherapy | 0.060 | ||||
No | 98 (33.6) | 46 (40.0) | 52 (29.4) | ||
Yes | 194 (66.4) | 69 (60.0) | 125 (70.6) | ||
Death | 0.001 | ||||
No | 168 (57.5) | 80 (69.6) | 88 (49.7) | ||
Yes | 124 (42.5) | 35 (30.4) | 89 (50.3) | ||