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Table 2 Univariate and multivariate analyses of prognostic parameters for overall survival

From: Alpha-fetoprotein normalization as a prognostic surrogate in small hepatocellular carcinoma after stereotactic body radiotherapy: a propensity score matching analysis

Variables Univariate Analyses Mutivariate Analyses
P (Cox regression) HR 95 % CI P (Cox regression) HR 95 % CI
Age 0.035 1.05 1.01-1.09 0.004 1.08 1.03-1.14
Gender 0.654 1.19 0.56-2.55 - - -
ECOG PS (0 vs. 1–2) 0.129 1.72 0.85-3.46 - - -
Child-Pugh (A vs. B) 0.011 2.52 1.24-5.13 0.142 2.72 0.72-10.31
Tumor size (cm) 0.016 1.52 1.08-2.15 0.008 1.66 1.14-2.40
preAFP (ng/mL) 0.436 1.00 1.00-1.00 - - -
ALT 0.898 1.01 0.99-1.01 - - -
Albumin 0.050 0.53 0.28-1.00 0.379 1.62 0.55-4.72
Bilirubin 0.027 1.58 1.05-2.36 0.258 1.43 0.77-2.70
INR 0.065 7.99 0.88-72.87 0.400 4.48 0.14-146.79
Radiation dose 0.018 0.94 0.89-0.99 0.079 0.95 0.90-1.01
AFP normalization (yes vs. no) 0.028 0.45 0.22-0.92 0.005 0.31 0.14-0.70
  1. Abbreviations: HR hazard ratio, CI confidence interval, ECOG Eastern Cooperative Oncology Group performance status, HBs-Ag hepatitis B surface-antigen, preAFP pre-treatment alpha-fetoprotein, ALT alanine aminotransferase, INR international normalized ratio