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Table 2 Univariate and multivariate analyses of prognostic parameters for overall survival

From: Alpha-fetoprotein normalization as a prognostic surrogate in small hepatocellular carcinoma after stereotactic body radiotherapy: a propensity score matching analysis

Variables

Univariate Analyses

Mutivariate Analyses

P (Cox regression)

HR

95 % CI

P (Cox regression)

HR

95 % CI

Age

0.035

1.05

1.01-1.09

0.004

1.08

1.03-1.14

Gender

0.654

1.19

0.56-2.55

-

-

-

ECOG PS (0 vs. 1–2)

0.129

1.72

0.85-3.46

-

-

-

Child-Pugh (A vs. B)

0.011

2.52

1.24-5.13

0.142

2.72

0.72-10.31

Tumor size (cm)

0.016

1.52

1.08-2.15

0.008

1.66

1.14-2.40

preAFP (ng/mL)

0.436

1.00

1.00-1.00

-

-

-

ALT

0.898

1.01

0.99-1.01

-

-

-

Albumin

0.050

0.53

0.28-1.00

0.379

1.62

0.55-4.72

Bilirubin

0.027

1.58

1.05-2.36

0.258

1.43

0.77-2.70

INR

0.065

7.99

0.88-72.87

0.400

4.48

0.14-146.79

Radiation dose

0.018

0.94

0.89-0.99

0.079

0.95

0.90-1.01

AFP normalization (yes vs. no)

0.028

0.45

0.22-0.92

0.005

0.31

0.14-0.70

  1. Abbreviations: HR hazard ratio, CI confidence interval, ECOG Eastern Cooperative Oncology Group performance status, HBs-Ag hepatitis B surface-antigen, preAFP pre-treatment alpha-fetoprotein, ALT alanine aminotransferase, INR international normalized ratio