TY - JOUR AU - Liu, Guilai AU - Honisch, Sabina AU - Liu, Guoxing AU - Schmidt, Sebastian AU - Alkahtani, Saad AU - AlKahtane, Abdullah A. AU - Stournaras, Christos AU - Lang, Florian PY - 2015 DA - 2015/12/21 TI - Up-regulation of Orai1 expression and store operated Ca2+ entry following activation of membrane androgen receptors in MCF-7 breast tumor cells JO - BMC Cancer SP - 995 VL - 15 IS - 1 AB - Membrane androgen receptors (mAR) are functionally expressed in a variety of tumor-cells including the breast tumor-cell line MCF-7. They are specifically activated by testosterone albumin conjugates (TAC). The mAR sensitive signaling includes activation of Ras-related C3 botulinum toxin substrate 1 (Rac1) and reorganization of the actin filament network. Signaling of tumor-cells may further involve up-regulation of pore forming Ca2+ channel protein Orai1, which accomplishes store operated Ca2+ entry (SOCE). This study explored the regulation of Orai1 abundance and SOCE by mAR. SN - 1471-2407 UR - https://doi.org/10.1186/s12885-015-2014-2 DO - 10.1186/s12885-015-2014-2 ID - Liu2015 ER -