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Fig. 3 | BMC Cancer

Fig. 3

From: All-trans retinoic acid synergizes with topotecan to suppress AML cells via promoting RARα-mediated DNA damage

Fig. 3

Mitochondrial damage was involved in caspase-dependent apoptosis. a and b Effects of TPT, ATRA, or combination for 24 h on loss of mitochondrial membrane potential in HL60 cells were detected by flow cytometry after JC-1 staining. b The rates of red to green after HL60 Cells treated with TPT, ATRA, or combination for 24 h. c Effects of TPT, ATRA, or combination on Bcl-2, Bax and Cytochrome C protein expression were analyzed by western blot

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BMC Cancer

ISSN: 1471-2407

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