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Table 1 Plasma biomarkers in HF and LF diet fed animals. Values are mean ± SEM. P < 0.05 was considered for statistically significant differences (marked with an asterisk)

From: MicroRNA expression analysis in high fat diet-induced NAFLD-NASH-HCC progression: study on C57BL/6J mice

Marker

3M HF

3M LF

P3M

6M HF

6M LF

P6M

12M HF

12M LF

P12M

ALT (U/l)

43.2 ± 3.5

23.3 ± 3

0.001*

70.5 ± 11.7

50.2 ± 18.9

0.16

89 ± 23

45.6 ± 6.7

0.03*

AST (U/l)

204.8 ± 59.3

155.3 ± 46.2

0.27

135.33 ± 20.4

200.78 ± 50.7

0.33

156.8 ± 24.2

202.9 ± 32.1

0.12

GLUC (mg/dl)

491.6 ± 56.3

425 ± 30.2

0.19

452.33 ± 13.8

359.56 ± 25.4

0.07

388.5 ± 32.9

398.2 ± 30.3

0.39

TRIG (mg/dl)

139.6 ± 8.7

87.2 ± 6.8

<0.001*

122.6 ± 10.4

72.4 ± 5.2

0.002*

100.7 ± 7.6

82.2 ± 6.2

0.06

CHOL (mg/dl)

214.1 ± 10.6

134 ± 7.9

<0.001*

233.78 ± 10.1

119.33 ± 8.8

<0.001*

208.3 ± 18.6

173.2 ± 10.1

0.06

DLDL (mg/dl)

10.1 ± 0.87

7.2 ± 0.6

0.008*

14.3 ± 1.6

8 ± 1.1

0.005*

15.1 ± 1.7

12.6 ± 1

0,07

UHDL (mg/dl)

112.6 ± 4

73.2 ± 3.8

0.002*

107.33 ± 3.3

61 ± 3.8

<0.001*

100.1 ± 6.5

80 ± 2.4

0.01*

  1. ALT alanine aminotransferase, AST aspartate aminotransferase, GLUC glucose, TRIG triglycerides, CHOL cholesterol, DLDL direct low density lipoprotein, UHDL ultra high density lipoprotein assay