Fig. 1
Expression patterns of four proteins according to histology. a Immunohistochemical staining of 4 proteins was performed in 372 formalin-fixed paraffin-embedded tissues. Representative positive staining is shown in adenocarcinoma (upper) and squamous cell carcinoma (lower). (Magnification ×200). b Prevalence of abnormal expression of 4 proteins was compared according to histology. P-values were based on Pearson’s chi-square or Fisher’s exact test. c-e Correlations among expression levels of 4 proteins were analyzed using Spearman’s rank correlation coefficient in adenocarcinoma (c), squamous cell carcinoma (d), and other cell types (e). The numbers on either side of plots indicate composite scores that were calculated by multiplying the intensity score and the proportion score of positive staining tumor cells. Violet color indicates a significant Spearman’s correlation between two proteins (P < 0.05)