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Fig. 6 | BMC Cancer

Fig. 6

From: In vitro and in vivo evaluation of the radiosensitizing effect of a selective FGFR inhibitor (JNJ-42756493) for rectal cancer

Fig. 6

Radiosensitizing effect in vivo. Mice bearing NCI-H716 (a) and Caco2 (b) xenograft tumors were treated with FGFR inhibitor with or without a single dose of radiotherapy at day 12 of the anti-FGFR treatment (▪ ). Control tumor-bearing animals received vehicle ( x). Relative tumor volumes (RTV) are shown. The line under the graph represents the period of drug treatment. All data points are mean ± STDEV of at least 10 tumors per treatment group. NCI-H716 data are representative for one of two independent experiments. c, d Effect of irradiation in treated tumors after drug treatment (TP1) and at the end of the experiment (TP2). Columns indicate mean ± STDEV of at least 20 tumor sections per treatment group. Significantly different from one another (p < 0.05; two-tailed student’s t-test)

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