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Table 3 Accuracy of models: Validated C-statistics with confidence intervals through model training on 70 % of subjects and testing on 30 %

From: Accuracy of volatile urine biomarkers for the detection and characterization of lung cancer

 

Urine Only

Urine + Clinical

Sensitivity (%)

Specificity (%)

All cancer vs. control

0.795 (0.768-0.823)

0.810 (0.782-0.838)

81.4 (77.9-84.9)

60.0 (56.9-63.1)

NSCLC vs. control

0.804 (0.783-0.825)

0.809 (0.782-0.836)

80.0 (76.8-83.2)

64.7 (60.8-68.6)

Adenocarcinoma vs. control

0.900 (0.879-0.920)

0.917 (0.899-0.936)

73.3 (69.1-77.6)

89.7 (87.6-91.8)

Squamous vs. control

0.821 (0.797-0.847)

0.821 (0.790-0.853)

60.0 (55.3-64.7)

87.9 (84.4-91.4)

Stage I vs. control

0.873 (0.848-0.90)

0.875 (0.856-0.894)

49.3 (44.9-53.7)

92.8 (89.5-96.1)

Stage I Adenocarcinoma vs. control

0.875 (0.843-0.906)

0.876 (0.846-0.906)

36.0 (27.7-44.3)

96.9 (95.2-98.6)

Stage I Squamous vs. control

0.940 (0.925-0.955)

0.938 (0.923-0.953)

46.7 (39.4-53.9)

97.6 (96.5-98.7)

Adenocarcinoma vs. Squamous

0.849 (0.828-0.87)

0.859 (0.831-0.887)

84.0 (80.8-87.3)

72.7 (67.2-78.2)

Stage I vs. IV

0.922 (0.892-0.952)

0.922 (0.892-0.952)

92.7 (90.2-95.2)

68.0 (60.3-75.7)

All cancer vs. control (matched)

0.968 (0.954-0.982)

0.970 (0.954-0.986)

95.5 (92.4-98.6)

88.0 (81.2-94.8)

NSCLC vs. control (matched)

0.977 (0.957-0.997)

0.987 (0.977-0.997)

86.7 (83.6-89.8)

96.0 (92.8-99.2)