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Table 3 Sensitivity and specificity of UPLC-MS profiles, AFP and individual peaks for HCC diagnosis

From: Serum lipidomic profiling as a useful tool for screening potential biomarkers of hepatitis B-related hepatocellular carcinoma by ultraperformance liquid chromatography–mass spectrometry

Test Sensitivity (%) Specificity (%) ROC AUC
HCC versus LC    
 4-ion UPLC-MS model 78.1 63.6 0.819b,c
 AFP20 ng/mL 37.5 93.3 0.779d
 AFP200 ng/mL 18.8 100.0 0.779d
 4-ion UPLC-MS model 75.0 83.3 0.856
  + AFP20 ng/mL a
HCC versus CHB    
 4-ion UPLC-MS model 93.8 80.0 0.864e,f
 2-ion UPLC-MS model 96.9 80.0 0.933g
 RT 3.40_773.5478 n 100.0 100.0 1.000
 RT 1.87_534.3902 m/z 100.0 100.0 1.000
 RT 6.25_369.3538 m/z 100.0 100.0 1.000
 RT 3.45_822.5670 m/z 100.0 100.0 1.000
 RT 3.59_770.5691 m/z 100.0 100.0 1.000
 RT 4.23_851.6090 m/z 100.0 100.0 1.000
 RT 3.99_826.5920 m/z 100.0 100.0 1.000
HCC versus HS    
 4-ion UPLC-MS model 90.6 88.2 0.946
  1. ROC receiver operating characteristic, AUC area under the curve, HCC hepatocellular carcinoma, LC liver cirrhosis, AFP alpha-fetoprotein, UPLC ultra performance liquid chromatography, MS mass spectrometry, CHB chronic hepatitis B, RT retention time, n neutral, m/z mass to charge ratio, HS healthy subjects. aCombination of the 4-ion UPLC-MS model and AFP20 ng/mL. bCompared with AFP20 ng/mL or AFP200 ng/mL, P = 0.616. cCompared with 4-ion UPLC-MS model + AFP20 ng/mL, P = 0.610. dCompared with 4-ion UPLC-MS model + AFP20 ng/mL, P = 0.312. eCompared with 2-ion UPLC-MS model, P = 0.241. fCompared with individual ions, P = 0.047. gCompared with individual ions, P = 0.005
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