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Table 3 Sensitivity and specificity of UPLC-MS profiles, AFP and individual peaks for HCC diagnosis

From: Serum lipidomic profiling as a useful tool for screening potential biomarkers of hepatitis B-related hepatocellular carcinoma by ultraperformance liquid chromatography–mass spectrometry

Test

Sensitivity (%)

Specificity (%)

ROC AUC

HCC versus LC

   

 4-ion UPLC-MS model

78.1

63.6

0.819b,c

 AFP20 ng/mL

37.5

93.3

0.779d

 AFP200 ng/mL

18.8

100.0

0.779d

 4-ion UPLC-MS model

75.0

83.3

0.856

  + AFP20 ng/mL a

HCC versus CHB

   

 4-ion UPLC-MS model

93.8

80.0

0.864e,f

 2-ion UPLC-MS model

96.9

80.0

0.933g

 RT 3.40_773.5478 n

100.0

100.0

1.000

 RT 1.87_534.3902 m/z

100.0

100.0

1.000

 RT 6.25_369.3538 m/z

100.0

100.0

1.000

 RT 3.45_822.5670 m/z

100.0

100.0

1.000

 RT 3.59_770.5691 m/z

100.0

100.0

1.000

 RT 4.23_851.6090 m/z

100.0

100.0

1.000

 RT 3.99_826.5920 m/z

100.0

100.0

1.000

HCC versus HS

   

 4-ion UPLC-MS model

90.6

88.2

0.946

  1. ROC receiver operating characteristic, AUC area under the curve, HCC hepatocellular carcinoma, LC liver cirrhosis, AFP alpha-fetoprotein, UPLC ultra performance liquid chromatography, MS mass spectrometry, CHB chronic hepatitis B, RT retention time, n neutral, m/z mass to charge ratio, HS healthy subjects. aCombination of the 4-ion UPLC-MS model and AFP20 ng/mL. bCompared with AFP20 ng/mL or AFP200 ng/mL, P = 0.616. cCompared with 4-ion UPLC-MS model + AFP20 ng/mL, P = 0.610. dCompared with 4-ion UPLC-MS model + AFP20 ng/mL, P = 0.312. eCompared with 2-ion UPLC-MS model, P = 0.241. fCompared with individual ions, P = 0.047. gCompared with individual ions, P = 0.005