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Table 2 Top 10 most up- and downregulated genes induced by the 500-mW PDT regimen

From: Low-power photodynamic therapy induces survival signaling in perihilar cholangiocarcinoma cells

Gene:

Full name:

Function:

FOS

FBJ murine osteosarcoma viral oncogene homolog

Inflammation, cellular response to ROS, DNA methylation

DUSP6

dual specificity phosphatase 6

Inactivation of MAPK activity

KREMEN2

kringle containing transmembrane protein 2

Wnt receptor signaling pathway

ATF3

activating transcription factor 3

Response to stress

HSPA1A

heat shock 70 kDa protein 1A

Response to unfolded protein, ubiquitin protein ligase binding

IL8

interleukin 8

Angiogenesis, chemotaxis, inflammation

RHOB

ras homolog family member B

GTP binding, apoptotic process, cellular response to H2O2

SNORD38A

small nucleolar RNA, C/D box 38A

 

FOSB

FBJ murine osteosarcoma viral oncogene homolog B

Transcription factor binding

CXCL1

chemokine (C-X-C motif) ligand 1

Cell proliferation, chemotaxis, inflammation

SOX21

SRY (sex determining region Y)-box 21

Transcription from RNA polymerase II promoter, stem cell differentiation

CHAC1

ChaC, cation transport regulator homolog 1

Intrinsic apoptotic signaling pathway in response to ER stress, negative regulator of Notch signaling pathway

CDKN1B

cyclin-dependent kinase inhibitor 1B

Cell cycle arrest

NEDD9

neural precursor cell expressed, developmentally down-regulated 9

Cell adhesion, cell division, cytoskeleton organization

AY358241

STC2

stanniocalcin 2

Cellular calcium ion homeostasis

FBXO32

F-box protein 32

Protein ubiquitination, response to denervation involved in regulation of muscle adaptation

EFNA1

ephrin-A1

Activation of MAPK activity, cell migration, aortic valve morphogenesis

BMF

Bcl2 modifying factor

Positive regulation of intrinsic apoptotic signaling pathway

DDIT4

DNA-damage-inducible transcript 4

Response to hypoxia, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of TOR signaling cascade

  1. Gene functions were obtained from The Gene Ontology Consortium (http://www.geneontology.org/)