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Table 1 Cytotoxicity of silvestrol on human melanoma cells. Concentration-dependent response for silvestrol-induced cytotoxicity in MDA-MB-435 cells. Melanoma cells were treated with vinblastine, silvestrol, bortezomib, homoharringtonine, and SAHA for 3 days. Cytotoxicity was determined by the MTS assay with the viability of control cells defined as 100 %. Dose-response data represent mean viability ± SE (n = 3 wells per treatment)

From: Silvestrol induces early autophagy and apoptosis in human melanoma cells

  IC50 (nM)
Vinblastine 1.3
Silvestrol 1.6
Bortezomib 5.7
Homoharringtonine 20
SAHA 475