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Table 1 Characteristics of the studies included for the meta-analysis

From: Lgr5 expression is a valuable prognostic factor for colorectal cancer: evidence from a meta-analysis

First author

Year

Country

Patient (M/F)

Age (year)

Technology

Lgr5 positive threshold

HR (95 % CI) of OS

HR (95 % CI) of DFS

Quality score

Liu

2014

China

363(200/166)

59mean

IHC

NA

2.604 (1.894–3.584)

NA

7

He

2014

China

53(29/24)

NA

IHC

NA

2.482 (1.52–4.283)

NA

7

Gao

2014

China

44(22/20)

59median

IHC

The percentage of stained cells ≥ 10 %

2.299 (0.922–5.714)

NA

6

Wu

2012

China

192(120/72)

62median

IHC

Multiplying the intensity and the quantity score > 5

2.768 (1.619–4.732)

NA

8

Hsu

2013

China

296(169/127)

63.5mean

IHC

The percentage of stained cells multiplied by the intensity scores ≥180

NA

2.21 (1.11–4.37)

7

Saiqusa

2012

Japan

52(41/11)

64.5median

IHC

The percentage of stained cells ≥ 50 %

1.061 (0.299–3.771)

4.942 (1.39–17.577)

6

Ziskin

2012

America

891(467/424)

71.4mean

ISH

Intensity score >1

1.15 (0.95–1.4)

NA

7

Valladares-Ayerbes

2012

Spain

54(33/21)

62.7mean

QRT-PCR

11.6

2.517 (0.924–6.858)

2.995 (1.192–7.527)

8

Takahashi

2011

Japan

180(105/75)

NA

QRT-PCR

Median value

0.909 (0.535–1.543)

3.3 (1.49–7.33)

6

Bao

2012

China

246(131/115)

63mean

IHC

The percentage of stained cells ≥ 5 %

1.122 (0.866–1.448)

NA

4

Peng

2010

China

169(101/68)

57mean

IHC

The percentage of stained cells ≥ 10 %

2.16 (1.35–3.45)

NA

7

Takeda

2010

Japan

60(32/28)

65.7mean

IHC

The percentage of stained cells ≥ 5 %

NA

NA

7