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Table 2 Subgroup analysis of pooled hazard ratios of colorectal patients with Lgr5 overexpression

From: Lgr5 expression is a valuable prognostic factor for colorectal cancer: evidence from a meta-analysis

      Heterogeneity  
Stratified analysis Number of studies Number of patients Pooled HR (95 % CI) P value I2(%) P value Interaction p value
Study location        0.518
 Asia 8 1299 1.81 (1.27–2.58) 0.001 76.2 0.000  
 Europe and America 2 945 1.45 (0.72–2.92) 0.299 55.8 0.133  
Number of patients        0.38
 >100 6 2041 1.6 (1.12–2.29) 0.01 85 0.043  
 <100 4 203 2.26 (1.53–3.34) 0.000 0 0.673  
Method of measurement        0.15
 IHC 7 1119 2.01 (1.39–2.89) 0.000 74.6 0.001  
 ISH 1 891 1.15 (0.95–1.4) 0.158    
 qRT-PCR 2 234 1.38 (0.52–3.68) 0.521 67.8 0.078  
NOS score        0.055
 >6 6 1669 2.12 (1.41–3.19) 0.000 82.8 0.000  
6 4 575 1.13 (0.9–1.4) 0.291 55.9 0.393