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Table 1 Characteristics of the studies included for the meta-analysis

From: Lgr5 expression is a valuable prognostic factor for colorectal cancer: evidence from a meta-analysis

First author Year Country Patient (M/F) Age (year) Technology Lgr5 positive threshold HR (95 % CI) of OS HR (95 % CI) of DFS Quality score
Liu 2014 China 363 (200/166) 59mean IHC NA 2.604 (1.894–3.584) NA 7
He 2014 China 53 (29/24) NA IHC NA 2.482 (1.52–4.283) NA 7
Gao 2014 China 44 (22/20) 59median IHC The percentage of stained cells ≥ 10 % 2.299 (0.922–5.714) NA 6
Wu 2012 China 192 (120/72) 62median IHC Multiplying the intensity and the quantity score > 5 2.768 (1.619–4.732) NA 8
Hsu 2013 China 296 (169/127) 63.5mean IHC The percentage of stained cells multiplied by the intensity scores ≥180 NA 2.21 (1.11–4.37) 7
Saiqusa 2012 Japan 52 (41/11) 64.5median IHC The percentage of stained cells ≥ 50 % 1.061 (0.299–3.771) 4.942 (1.39–17.577) 6
Ziskin 2012 America 891 (467/424) 71.4mean ISH Intensity score >1 1.15 (0.95–1.4) NA 7
Valladares-Ayerbes 2012 Spain 54 (33/21) 62.7mean QRT-PCR 11.6 2.517 (0.924–6.858) 2.995 (1.192–7.527) 8
Takahashi 2011 Japan 180 (105/75) NA QRT-PCR Median value 0.909 (0.535–1.543) 3.3 (1.49–7.33) 6
Bao 2012 China 246 (131/115) 63mean IHC The percentage of stained cells ≥ 5 % 1.122 (0.866–1.448) NA 4
Peng 2010 China 169 (101/68) 57mean IHC The percentage of stained cells ≥ 10 % 2.16 (1.35–3.45) NA 7
Takeda 2010 Japan 60 (32/28) 65.7mean IHC The percentage of stained cells ≥ 5 % NA NA 7