Potential anti-cancer effect of N-hydroxy-7-(2-naphthylthio) heptanomide (HNHA), a novel histone deacetylase inhibitor, for the treatment of thyroid cancer

Table 1 Half-maximal inhibitory concentration (IC₅₀) values were determined using a cell proliferation assay

Cell line	Histopathology	Animal	Cell proliferation (IC₅₀*) (μM)
			HNHA	TSA	SAHA
SNU-80	Thyroid: anaplastic	Human	2.74 (±0.9)^*	4.02 (±1.0)	6.74 (±1.1)
SNU-790	Thyroid: papillary	Human	2.32 (±1.0)^*	3.91 (±1.2)	5.31 (±1.4)

Each data point denotes the mean of three independent IC₅₀ values calculated from triplicate MTT assays
SD standard deviation
*reflect that were most significantly different between the groups

ISSN: 1471-2407