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Table 3 Multivariable survival analysis of TSR and other prognostic factors

From: The prognostic significance of tumour-stroma ratio in endometrial carcinoma

  Overall survival Disease-free survival
Factor HR (95 % CI) P HR (95 % CI) P
TSR ( ≥1.30 vs. <1.30) 1.18 (0.56–2.47) 0.667 1.12 (0.57–2.18) 0.740
Age (continuous) 1.07 (1.05–1.09) <0.001 1.06 (1.04–1.08) <0.001
Stage (FIGO 2009)     
 I Referent Referent Referent Referent
 II 1.12 (0.60–2.09) 0.731 1.10 (0.60–2.00) 0.603
 III 1.69 (1.07–2.67) 0.024 1.64 (1.06–2.54) 0.028
 IV 8.38 (4.75–14.74) <0.001 6.77 (3.92–11.70) <0.001
Grade     
 1 Referent Referent Referent Referent
 2 1.06 (0.61–1.86) 0.835 0.95 (0.57–1.61) 0.857
 3 1.96 (1.20–3.21) 0.007 1.61 (1.02–2.55) 0.042
Lymphovascular invasion (yes vs. no) 1.94 (1.26–2.90) 0.002 1.95 (1.30–2.94) 0.001
  1. Multivariable Cox proportional hazards regression for overall and disease free survival
  2. Abbreviations: CI confidence interval, FIGO International Federation of Gynaecology and Obstetrics, HR hazard ratio, TSR tumour-stroma ratio