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Table 3 Multivariable survival analysis of TSR and other prognostic factors

From: The prognostic significance of tumour-stroma ratio in endometrial carcinoma

 

Overall survival

Disease-free survival

Factor

HR (95 % CI)

P

HR (95 % CI)

P

TSR ( ≥1.30 vs. <1.30)

1.18 (0.56–2.47)

0.667

1.12 (0.57–2.18)

0.740

Age (continuous)

1.07 (1.05–1.09)

<0.001

1.06 (1.04–1.08)

<0.001

Stage (FIGO 2009)

    

 I

Referent

Referent

Referent

Referent

 II

1.12 (0.60–2.09)

0.731

1.10 (0.60–2.00)

0.603

 III

1.69 (1.07–2.67)

0.024

1.64 (1.06–2.54)

0.028

 IV

8.38 (4.75–14.74)

<0.001

6.77 (3.92–11.70)

<0.001

Grade

    

 1

Referent

Referent

Referent

Referent

 2

1.06 (0.61–1.86)

0.835

0.95 (0.57–1.61)

0.857

 3

1.96 (1.20–3.21)

0.007

1.61 (1.02–2.55)

0.042

Lymphovascular invasion (yes vs. no)

1.94 (1.26–2.90)

0.002

1.95 (1.30–2.94)

0.001

  1. Multivariable Cox proportional hazards regression for overall and disease free survival
  2. Abbreviations: CI confidence interval, FIGO International Federation of Gynaecology and Obstetrics, HR hazard ratio, TSR tumour-stroma ratio