Table 4 Associations between pill-years^a of NSAID use and breast cancer by menopause status, the Sister Study (2003-2013)

Use of any NSAIDs, py

0.091

 <0.75

431

1. (Ref.)

576

1. (Ref.)

 0.75- < 14

91

0.84 (0.67–1.05)

220

1.07 (0.92–1.25)

 14- < 49

113

1.03 (0.83–1.27)

329

1.05 (0.91–1.20

 ≥ 49

60

0.66 (0.50–0.87)

298

0.95 (0.82–1.09)

 P for trend

0.025

0.641

Aspirin, py

0.038

 <0.75

606

1. (Ref.)

883

1. (Ref.)

 0.75- < 14

35

0.81 (0.58–1.14)

156

1.21 (1.02–1.44)

 14- < 49

40

0.91 (0.66–1.25)

226

1.00 (0.86–1.16)

 ≥ 49

14

0.57 (0.33–0.98)

158

1.03 (0.87–1.23)

 P for trend

0.038

0.654

COXibs^b, py

0.200

 <0.75

659

1. (Ref.)

1245

1. (Ref.)

 0.75- < 21

27

0.88 (0.60–1.30

112

1.09 (0.90–1.32)

 ≥ 21

9

0.62 (0.32–1.22)

66

0.91 (0.71–1.17)

 P for trend

0.141

0.812

Non-aspirin, non-COXib NSAIDs, py

0.508

 <0.75

497

1. (Ref.)

973

1. (Ref.)

 0.75- < 14

78

0.93 (0.73–1.18)

170

1.00 (0.85–1.18)

 14- < 49

79

1.04 (0.82–1.33)

162

1.00 (0.85–1.19)

 ≥ 49

41

0.73 (0.53–1.01)

118

0.87 (0.72–1.06)

 P for trend

0.182

0.314