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Table 3 Univariate analysis

From: High EGFR protein expression and exon 9 PIK3CA mutations are independent prognostic factors in triple negative breast cancers

  N RFS OS
   Events 5-y RFS HR (95 % CI) Events 5-y OS HR (95 % CI)
Age        
 <55 years 98 21 79.9 1 17 84.1 1
 ≥55 years 106 31 72.6 1.29 [0.74; 2.24] 30 78.9 1.51 [0.83; 2.73]
   p = 0.370 p = 0.174
T        
 T1 84 11 88.3 1 11 90.7 1
 T2+ 120 41 67.5 2.91 [1.50; 5.67] 36 74.7 2.48 [1.26; 4.88]
   p = 0.001 p = 0.006
N        
 N- 132 20 86.9 1 21 89.0 1
 N+ 72 32 56.1 3.56 [2.03; 6.22] 26 66.8 2.58 [1.45; 4.59]
   p < 0.001 p = 0.001
SBR-EE grade        
 1-2 69 17 79.9 1 15 86.3 1
 3 132 35 73.7 1.13 [0.63; 2.02] 32 78.4 1.21 [0.65; 2.24]
   p = 0.676 p = 0.541
Histology        
 Ductal 163 42 75.4 1 40 80.0 1
 Lobular/Other 41 10 78.7 0.93 [0.47; 1.86] 7 86.6 0.67 [0.30; 1.49]
   p = 0.848 p = 0.325
Adjuvant CT        
 No 60 21 66.7 1 24 69.1 1
 Yes 142 31 80.1 0.60 [0.35; 1.05] 23 86.8 0.40 [0.23; 0.71]
   p = 0.070 p = 0.001
EGFR status        
 Normal/Deletion 165 41 78.0 1 35 81.8 1
 Ampl./Polysomy 38 11 65.9 1.36 [0.69; 2.65] 12 78.5 1.80 [0.93; 3.49]
   p = 0.368 p = 0.075
PIK3CA status        
 No mutation 173 40 78.0 1 36 83.2 1
 Exon 9 14 7 61.5 2.62 [1.17; 5.86] 7 69.2 2.55 [1.13; 5.74]
 Exon 20 17 5 67.8 1.38 [0.54; 3.50] 4 70.5 1.23 [0.44; 3.46]
   p = 0.048 p = 0.063
EGFR protein level       
 Lower and middle tercile 126 30 79.4 1 27 84.1 1
 Upper tercile 63 20 66.0 1.54 [0.87; 2.72] 17 73.8 1.42 [0.78; 2.62]
   p = 0.131 p = 0.247
PTEN status        
 No deletion 157 38 78.5 1 33 83.4 1
 Deletion 43 13 67.7 1.38 [0.74; 2.60] 13 75.1 1.66 [0.87; 3.16]
   p = 0.309 p = 0.117