N | RFS | OS | |||||
---|---|---|---|---|---|---|---|
Events | 5-y RFS | HR (95 % CI) | Events | 5-y OS | HR (95 % CI) | ||
Age | |||||||
<55 years | 98 | 21 | 79.9 | 1 | 17 | 84.1 | 1 |
≥55 years | 106 | 31 | 72.6 | 1.29 [0.74; 2.24] | 30 | 78.9 | 1.51 [0.83; 2.73] |
p = 0.370 | p = 0.174 | ||||||
T | |||||||
T1 | 84 | 11 | 88.3 | 1 | 11 | 90.7 | 1 |
T2+ | 120 | 41 | 67.5 | 2.91 [1.50; 5.67] | 36 | 74.7 | 2.48 [1.26; 4.88] |
p = 0.001 | p = 0.006 | ||||||
N | |||||||
N- | 132 | 20 | 86.9 | 1 | 21 | 89.0 | 1 |
N+ | 72 | 32 | 56.1 | 3.56 [2.03; 6.22] | 26 | 66.8 | 2.58 [1.45; 4.59] |
p < 0.001 | p = 0.001 | ||||||
SBR-EE grade | |||||||
1-2 | 69 | 17 | 79.9 | 1 | 15 | 86.3 | 1 |
3 | 132 | 35 | 73.7 | 1.13 [0.63; 2.02] | 32 | 78.4 | 1.21 [0.65; 2.24] |
p = 0.676 | p = 0.541 | ||||||
Histology | |||||||
Ductal | 163 | 42 | 75.4 | 1 | 40 | 80.0 | 1 |
Lobular/Other | 41 | 10 | 78.7 | 0.93 [0.47; 1.86] | 7 | 86.6 | 0.67 [0.30; 1.49] |
p = 0.848 | p = 0.325 | ||||||
Adjuvant CT | |||||||
No | 60 | 21 | 66.7 | 1 | 24 | 69.1 | 1 |
Yes | 142 | 31 | 80.1 | 0.60 [0.35; 1.05] | 23 | 86.8 | 0.40 [0.23; 0.71] |
p = 0.070 | p = 0.001 | ||||||
EGFR status | |||||||
Normal/Deletion | 165 | 41 | 78.0 | 1 | 35 | 81.8 | 1 |
Ampl./Polysomy | 38 | 11 | 65.9 | 1.36 [0.69; 2.65] | 12 | 78.5 | 1.80 [0.93; 3.49] |
p = 0.368 | p = 0.075 | ||||||
PIK3CA status | |||||||
No mutation | 173 | 40 | 78.0 | 1 | 36 | 83.2 | 1 |
Exon 9 | 14 | 7 | 61.5 | 2.62 [1.17; 5.86] | 7 | 69.2 | 2.55 [1.13; 5.74] |
Exon 20 | 17 | 5 | 67.8 | 1.38 [0.54; 3.50] | 4 | 70.5 | 1.23 [0.44; 3.46] |
p = 0.048 | p = 0.063 | ||||||
EGFR protein level | |||||||
Lower and middle tercile | 126 | 30 | 79.4 | 1 | 27 | 84.1 | 1 |
Upper tercile | 63 | 20 | 66.0 | 1.54 [0.87; 2.72] | 17 | 73.8 | 1.42 [0.78; 2.62] |
p = 0.131 | p = 0.247 | ||||||
PTEN status | |||||||
No deletion | 157 | 38 | 78.5 | 1 | 33 | 83.4 | 1 |
Deletion | 43 | 13 | 67.7 | 1.38 [0.74; 2.60] | 13 | 75.1 | 1.66 [0.87; 3.16] |
p = 0.309 | p = 0.117 |