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Table 3 Univariate analysis

From: High EGFR protein expression and exon 9 PIK3CA mutations are independent prognostic factors in triple negative breast cancers

 

N

RFS

OS

  

Events

5-y RFS

HR (95 % CI)

Events

5-y OS

HR (95 % CI)

Age

       

 <55 years

98

21

79.9

1

17

84.1

1

 ≥55 years

106

31

72.6

1.29 [0.74; 2.24]

30

78.9

1.51 [0.83; 2.73]

  

p = 0.370

p = 0.174

T

       

 T1

84

11

88.3

1

11

90.7

1

 T2+

120

41

67.5

2.91 [1.50; 5.67]

36

74.7

2.48 [1.26; 4.88]

  

p = 0.001

p = 0.006

N

       

 N-

132

20

86.9

1

21

89.0

1

 N+

72

32

56.1

3.56 [2.03; 6.22]

26

66.8

2.58 [1.45; 4.59]

  

p < 0.001

p = 0.001

SBR-EE grade

       

 1-2

69

17

79.9

1

15

86.3

1

 3

132

35

73.7

1.13 [0.63; 2.02]

32

78.4

1.21 [0.65; 2.24]

  

p = 0.676

p = 0.541

Histology

       

 Ductal

163

42

75.4

1

40

80.0

1

 Lobular/Other

41

10

78.7

0.93 [0.47; 1.86]

7

86.6

0.67 [0.30; 1.49]

  

p = 0.848

p = 0.325

Adjuvant CT

       

 No

60

21

66.7

1

24

69.1

1

 Yes

142

31

80.1

0.60 [0.35; 1.05]

23

86.8

0.40 [0.23; 0.71]

  

p = 0.070

p = 0.001

EGFR status

       

 Normal/Deletion

165

41

78.0

1

35

81.8

1

 Ampl./Polysomy

38

11

65.9

1.36 [0.69; 2.65]

12

78.5

1.80 [0.93; 3.49]

  

p = 0.368

p = 0.075

PIK3CA status

       

 No mutation

173

40

78.0

1

36

83.2

1

 Exon 9

14

7

61.5

2.62 [1.17; 5.86]

7

69.2

2.55 [1.13; 5.74]

 Exon 20

17

5

67.8

1.38 [0.54; 3.50]

4

70.5

1.23 [0.44; 3.46]

  

p = 0.048

p = 0.063

EGFR protein level

      

 Lower and middle tercile

126

30

79.4

1

27

84.1

1

 Upper tercile

63

20

66.0

1.54 [0.87; 2.72]

17

73.8

1.42 [0.78; 2.62]

  

p = 0.131

p = 0.247

PTEN status

       

 No deletion

157

38

78.5

1

33

83.4

1

 Deletion

43

13

67.7

1.38 [0.74; 2.60]

13

75.1

1.66 [0.87; 3.16]

  

p = 0.309

p = 0.117