Fig. 6

Inhibition of tumor growth by erlotinib (ERL) in vivo. Mice were implanted with Ishikawa (a) or HEC-1A (b) and treated with ERL or TRA for 28 days. Tumor volume was measured twice a week. Data represent the means ± SEMs of three independent tumor volumes. *, decreased as compared to vehicle control, P < 0.05. c On day 28 after starting treatment, mice were euthanized and tumor was excised. The tissues were fixed in formalin and embedded in paraffin. Sections were taken from the paraffin-embedded tissue and HE stained. Top and upper middle panels, Ishikawa tumor; lower middle and bottom panels, HEC-1A tumor. Magnification × 200.Bars =1000 μm