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Fig. 5 | BMC Cancer

Fig. 5

From: BPIQ, a novel synthetic quinoline derivative, inhibits growth and induces mitochondrial apoptosis of lung cancer cells in vitro and in zebrafish xenograft model

Fig. 5

The effects of BPIQ on modulation of Bcl-2 family members in H1299 cells. Cells were subjected to treatment with vehicle control or the indicated doses of BPIQ. a Western blot showed the significantly decreased levels of IAP factors survivin and XIAP. b Western blot showed the increase in pro-apoptotic Bid, Bad and Bim protein levels. c Western blot showed BPIQ causes the changes of IAP factors and pro-apoptotic Bad in a time dependent-manner. β-actin was measured as an internal control. Each blot is representative of three independent experiments. d The effect of Bim knockdown on BPIQ-induced apoptosis of H1299 cells determined using a cytometry-based annexin v staining assay. *p < 0.05 for scramble siRNA versus. Bim siRNA

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