Skip to main content
Fig. 2 | BMC Cancer

Fig. 2

From: BPIQ, a novel synthetic quinoline derivative, inhibits growth and induces mitochondrial apoptosis of lung cancer cells in vitro and in zebrafish xenograft model

Fig. 2

BPIQ induced an accumulated G2/M population and aberrant polyploidy in H1299 cells. Cells were treated with the indicated doses (vehicle control, 1, 2, 5, and 10 μM) of BPIQ for 24 h, respectively. a The accumulation of the G2/M population in BPIQ-treated H1299 cells and vehicle controls at 24 h. b The quantification analysis of cell cycle distribution. Different letter notations indicate the statistical significance between BPIQ treatment and vehicle (a vs. b and a vs. c indicate the p < 0.005 and p < 0.001, respectively.). c Analysis of G2/M population. d Analysis of polyploidy. Data are presented as means ± S.D. (n = 3). Different letter notations indicate the statistical significance between drug treatment and vehicle (*p < 0.05 and **p < 0.001 respectively). e Western blot analysis demonstrating BPIQ-induced down-regulation of CDK1 and cyclin B protein levels. β-actin was measured as an internal control

Back to article page