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Table 2 Copy numbers of H3K4-specific demethylases and methyltransferases

From: The pan-HDAC inhibitor panobinostat acts as a sensitizer for erlotinib activity in EGFR-mutated and -wildtype non-small cell lung cancer cells

gene

KDM1A

KDM2A

KDM4A

KDM5A

KDM5B

KDM5C

KDM5D

SETD1A

SETD1B

KMT2A

KMT2B

KMT2C

KMT2D

HCC827

n

n

3

3

n

n

n

n

n

n

n

n

n

A549

1

n

1

n

n

n

n

n

n

n

n

n

n

NCI-H460

1

1

n

n

3

n

n

n

n

n

n

n

n

  1. Evaluation of copy numbers of seven demethylases and six methyltransferases that specifically target lysine 4 residues of histone H3 (H3K4)
  2. 0 = complete loss, 1 = 50 % loss, n = no loss or gain, 3 = 50 % gain and 4 = 100 % gain of genomic material, relative to ploidy (all percentages are approximate values computed with Affymetrix Genotyping Console Software)