Skip to main content

Table 2 Copy numbers of H3K4-specific demethylases and methyltransferases

From: The pan-HDAC inhibitor panobinostat acts as a sensitizer for erlotinib activity in EGFR-mutated and -wildtype non-small cell lung cancer cells

gene KDM1A KDM2A KDM4A KDM5A KDM5B KDM5C KDM5D SETD1A SETD1B KMT2A KMT2B KMT2C KMT2D
HCC827 n n 3 3 n n n n n n n n n
A549 1 n 1 n n n n n n n n n n
NCI-H460 1 1 n n 3 n n n n n n n n
  1. Evaluation of copy numbers of seven demethylases and six methyltransferases that specifically target lysine 4 residues of histone H3 (H3K4)
  2. 0 = complete loss, 1 = 50 % loss, n = no loss or gain, 3 = 50 % gain and 4 = 100 % gain of genomic material, relative to ploidy (all percentages are approximate values computed with Affymetrix Genotyping Console Software)