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Table 1 Baseline characteristics of 491 patients with nasopharyngeal carcinoma

From: The impact of the cumulative dose of cisplatin during concurrent chemoradiotherapy on the clinical outcomes of patients with advanced-stage nasopharyngeal carcinoma in an era of intensity-modulated radiotherapy

 

Low-dose group 14(2.9 %)

Medium-dose group 378(77.0 %)

High-dose group 99(20.2 %)

P value

Age(yr.),

   

0.081

  <45

7(50.0 %)

170(45.0 %)

57(57.6 %)

 

  ≥45

7(50.0 %)

208(55.0 %)

42(42.4 %)

 

Gender

   

0.284

  Female

6(42.9 %)

103(27.2 %)

132(26.9 %)

 

  Male

8(57.1 %)

275(72.8 %)

359(73.1 %)

 

T stage

   

0.960

  1

1(7.1 %)

23(6.1 %)

7(7.1 %)

 

  2

2(14.3 %)

68(18.0 %)

15(15.2 %)

 

  3

7(50.0 %)

217(57.4 %)

57(57.6 %)

 

  4

4(28.6 %)

70(18.5 %)

20(20.3 %)

 

N stage

   

0.306

  0

2(14.3 %)

55(14.6 %)

8(8.1 %)

 

  1

8(57.1 %)

140(37.0 %)

47(47.5 %)

 

  2

4(28.6 %)

159(42.1 %)

38(38.4 %)

 

  3

0(0)

24(6.3 %)

6(6.1 %)

 

Clinical stage

   

0.492

  2

3(21.4 %)

30(7.9 %)

9(9.1 %)

 

  3

8(57.1 %)

256(67.7 %)

64(64.6 %)

 

  4

3(21.4 %)

92(24.3 %)

26(26.3 %)

 

WHO type

   

0.418

  2

0(0)

15(4.5 %)

7(7.6 %)

 

  3

12(100.0 %)

316(95.5 %)

85(92.4 %)

 

ECOG score

   

0.859

  0

0(0)

8(2.1 %)

2(2.0 %)

 

  1

14(100.0 %)

370(97.9 %)

97(98.0 %)

 

ACE-27

   

0.159

  0

8(57.1 %)

296(78.1 %)

78(78.8 %)

 

  1

5(35.7 %)

71(18.7 %)

21(21.2 %)

 

  2

1(7.1 %)

12(3.2 %)

0(0)

 

  3

0(0)

0(0)

0(0)

 

EBV DNA

   

0.942

  ≥4000

8(57.1 %)

232(61.4 %)

60(60.6 %)

 

  <4000

6(42.9 %)

146(38.6 %)

39(39.4 %)

 

RT Dose(Gy), Median(range)

68.0(68.0-70.0)

68.0(66.0-70.0)

68.0(66.0-70.0)

0.359

VCA-IgA

   

0.431

Positive(≥1:80)

10(71.4 %)

314(83.1 %)

79(79.8 %)

 

Negative(<1:80)

4(28.6 %)

64(16.9 %)

20(20.2 %)

 

EA-IgA

   

0.425

Positive(≥1:10)

8(57.1 %)

276(73.0 %)

72(72.7 %)

 

Negative(<1:10)

6(42.9 %)

102(27.0 %)

27(27.3 %)

 

Median follow-up in months(range)

46.5(3–80)

48(1–88)

53(11–86)

0.018

  1. Abbreviations: yr year, WHO World Health Organization, ECOG Eastern Cooperative Oncology Group, EBV DNA Epstein–Barr virus deoxyribonucleic acid, RT radiotherapy
  2. P value < 0.05 indicates a statistically significant difference