Methylation status of COX-2 in blood leukocyte DNA and risk of gastric cancer in a high-risk Chinese population

BMC Cancer

Table 4 Association between COX-2 methylation and risk of progression to GC

	Hypermethylated^a	Hypomethylated	OR(95 % CI)^b	P ^b
IM (Progress to GC)	18(54.6)	15(45.5)	0.50(0.18-1.42)	0.19
n = 33	18(54.6)	15(45.5)	0.50(0.18-1.42)	0.19
IM (Not progress to GC)	69(69.7)	30(30.3)
n = 99	69(69.7)	30(30.3)
DYS (Progress to GC)	24(68.6)	11(31.4)	0.70(0.23–2.18)	0.54
n = 35	24(68.6)	11(31.4)	0.70(0.23–2.18)	0.54
DYS (Not progress to GC)	70(66.7)	35(33.3)
n = 105	70(66.7)	35(33.3)

^a Cut-off value was set as 2 %, according to the median COX-2 methylation level of SG/CAG group
^b Unconditional logistic regression analysis, adjusted for age, gender, smoking, drinking and H. pylori infection status

ISSN: 1471-2407