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Table 4 Association between COX-2 methylation and risk of progression to GC

From: Methylation status of COX-2 in blood leukocyte DNA and risk of gastric cancer in a high-risk Chinese population

  Hypermethylateda Hypomethylated OR(95 % CI)b P b
IM (Progress to GC) 18(54.6) 15(45.5) 0.50(0.18-1.42) 0.19
n = 33
IM (Not progress to GC) 69(69.7) 30(30.3)   
n = 99
DYS (Progress to GC) 24(68.6) 11(31.4) 0.70(0.23–2.18) 0.54
n = 35
DYS (Not progress to GC) 70(66.7) 35(33.3)   
n = 105
  1. a Cut-off value was set as 2 %, according to the median COX-2 methylation level of SG/CAG group
  2. b Unconditional logistic regression analysis, adjusted for age, gender, smoking, drinking and H. pylori infection status