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Table 2 Change of signaling pathways in Tg(RE:HSE:EGFP) zebrafish

From: RUNX1-Evi-1 fusion gene inhibited differentiation and apoptosis in myelopoiesis: an in vivo study

Term Regulate Counta %b P-Value Benjamini
Proteasome + 11 1.3 2.6E-9 2.8E-7
Cell cycle + 28 2.2 5.3E-8 3.7E-6
Glycolysis/Gluconeogenesis + 16 1.0 8.5E-6 7.0E-5
Tyrosine metabolism + 10 0.9 9.1E-6 3.9E-5
Tryptophan metabolism + 8 0.9 1.6E-5 4.1E-4
Drug metabolism + 7 0.8 5.1E-5 7.6E-3
Metabolism of xenobiotics by cytochrome P450 + 7 0.8 5.1E-3 7.6E-2
Androgen and estrogen metabolism + 8 0.9 7.0E-3 8.0E-2
PPAR signaling pathway + 6 0.7 7.2E-3 7.4E-2
Retinol metabolism + 4 0.5 8.4E-3 7.5E-2
Jak-STAT signaling pathway - 14 2.4 6.8E-10 8.3E-8
DNA replication - 15 1.1 3.5E-9 3.0E-7
Mismatch repair - 8 0.9 4.5E-7 1.8E-6
Homologous recombination - 12 0.9 8.9E-7 3.5E-5
Base excision repair - 12 1 2.7E-6 4.7E-5
Spliceosome - 22 1.6 2.9E-5 4.4E-4
Nucleotide excision repair - 18 1.2 6.3E-5 4.3E-4
p53 signaling pathway - 16 1.3 3.8E-4 8.3E-3
JNK signaling pathway - 7 1.2 4.0E-4 8.7E-3
Butanoate metabolism - 4 0.7 4.1E-4 2.7E-3
Transforming growth factor β - 14 1.1 6.3 E-4 7.3 E-3
Porphyrin and chlorophyll metabolism - 4 0.7 7.4E-4 7.8E-3
Arginine and proline metabolism - 5 0.9 7.8E-4 8.0E-3
  1. +: upregulated; −: downregulated. a: genes involved in the term. b: involved genes/total genes
  2. P-Value: the threshold of EASE Score, a modified Fisher Exact P-Value, for gene-enrichment analysis (<0.01). Benjamini: Benjamini and Hochberg’s false discovery rate (<0.01)