Table 2 Change of signaling pathways in Tg(RE:HSE:EGFP) zebrafish
From: RUNX1-Evi-1 fusion gene inhibited differentiation and apoptosis in myelopoiesis: an in vivo study
Term | Regulate | Counta | %b | P-Value | Benjamini |
|---|---|---|---|---|---|
Proteasome | + | 11 | 1.3 | 2.6E-9 | 2.8E-7 |
Cell cycle | + | 28 | 2.2 | 5.3E-8 | 3.7E-6 |
Glycolysis/Gluconeogenesis | + | 16 | 1.0 | 8.5E-6 | 7.0E-5 |
Tyrosine metabolism | + | 10 | 0.9 | 9.1E-6 | 3.9E-5 |
Tryptophan metabolism | + | 8 | 0.9 | 1.6E-5 | 4.1E-4 |
Drug metabolism | + | 7 | 0.8 | 5.1E-5 | 7.6E-3 |
Metabolism of xenobiotics by cytochrome P450 | + | 7 | 0.8 | 5.1E-3 | 7.6E-2 |
Androgen and estrogen metabolism | + | 8 | 0.9 | 7.0E-3 | 8.0E-2 |
PPAR signaling pathway | + | 6 | 0.7 | 7.2E-3 | 7.4E-2 |
Retinol metabolism | + | 4 | 0.5 | 8.4E-3 | 7.5E-2 |
Jak-STAT signaling pathway | - | 14 | 2.4 | 6.8E-10 | 8.3E-8 |
DNA replication | - | 15 | 1.1 | 3.5E-9 | 3.0E-7 |
Mismatch repair | - | 8 | 0.9 | 4.5E-7 | 1.8E-6 |
Homologous recombination | - | 12 | 0.9 | 8.9E-7 | 3.5E-5 |
Base excision repair | - | 12 | 1 | 2.7E-6 | 4.7E-5 |
Spliceosome | - | 22 | 1.6 | 2.9E-5 | 4.4E-4 |
Nucleotide excision repair | - | 18 | 1.2 | 6.3E-5 | 4.3E-4 |
p53 signaling pathway | - | 16 | 1.3 | 3.8E-4 | 8.3E-3 |
JNK signaling pathway | - | 7 | 1.2 | 4.0E-4 | 8.7E-3 |
Butanoate metabolism | - | 4 | 0.7 | 4.1E-4 | 2.7E-3 |
Transforming growth factor β | - | 14 | 1.1 | 6.3 E-4 | 7.3 E-3 |
Porphyrin and chlorophyll metabolism | - | 4 | 0.7 | 7.4E-4 | 7.8E-3 |
Arginine and proline metabolism | - | 5 | 0.9 | 7.8E-4 | 8.0E-3 |