Fig. 7From: RUNX1-Evi-1 fusion gene inhibited differentiation and apoptosis in myelopoiesis: an in vivo studyVPA changed some genes expression in Tg(RE:HSE:EGFP) embryos. VPA reduced the expression of skp2 and smad7, and upregulated p21 and p27, which inhibited the progress of cell proliferation. VPA significantly downregulated Bcl2, and meanwhile enhanced the expression of P53, Bax, JNK and JUN. Majority of these changes were concentration dependence. *P <0.05; **P < 0.01Back to article page