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Table 5 Multivariate analysis for association of HPV genotype and reflex LBC with CIN2 and CIN3+

From: Comparison of the Roche cobas® 4800 and Digene Hybrid Capture® 2 HPV tests for primary cervical cancer screening in the HPV FOCAL trial

 

CIN2

CIN3+

p value

Odds ratio (95 % CI)

p value

Odds ratio (95 % CI)

HPV genotype

0.60

 

0.0003

 

 16 vs. non-16 OHR

 

0.71 (0.33, 1.53)

 

5.11 (2.30, 11.37)

 18 vs. non-16/18 OHR

 

1.21 (0.42, 3.50)

 

2.62 (0.73, 9.49)

Reflex LBC

0.15

 

<0.0001

 

 High-gradea vs. NILM

 

2.23 (0.96, 5.17)

 

5.99 (2.53, 14.18)

 Low-gradeb vs. NILM

 

1.02 (0.50, 2.08)

 

0.54 (0.20, 1.49)

  1. aHigh-grade = ASCH + HSIL. bLow-grade = ASCUS + LSIL
  2. Abbreviations: OHR other high-risk HPV, LBC liquid-based cytology, NILM negative for intraepithelial lesions and malignancy, CIN cervical intraepithelial neoplasia, ASCUS atypical squamous cells undetermined significance, ASCH atypical squamous cells, cannot rule out high-grade; LSIL low-grade squamous intraepithelial lesion, HSIL high-grade squamous intraepithelial lesion
  3. Bolded type indicates statistically significant results
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BMC Cancer

ISSN: 1471-2407

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