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Table 2 Associations between SNP and breast cancer-specific mortality by chemotherapy for interactions showing p < 0.1 (LRT)* in the MARIE study and results of replication in BCAC studies

From: A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients

     

With chemotherapy

No chemotherapy

 

SNP

Alleles

MAF

Gene

Studya

HR

95 % CI

HR

95 % CI

p for interaction*

rs1052133

C > G

0.22

OGG1

MARIE

1.18

0.83

1.66

0.63

0.29

1.37

0.0601

  

0.22

 

BCAC

1.03

0.80

1.32

0.93

0.76

1.14

0.5446

rs2269112

G > A

0.16

OGG1

MARIE

1.41

0.97

2.06

0.89

0.40

1.99

0.0498

  

0.15

 

BCAC

1.00

0.76

1.31

1.03

0.82

1.30

0.8695

rs878156

A > G

0.07

PARP2

MARIE

0.88

0.50

1.54

2.78

1.15

6.73

0.0930

  

0.07

 

BCAC

0.67

0.43

1.06

1.32

1.00

1.75

0.0093

rs3136717

A > G

0.10

POLB

MARIE

1.18

0.74

1.90

0.19

0.05

0.78

0.0388

  

0.12

 

BCAC

0.78

0.55

1.11

0.94

0.74

1.20

0.3787

rs3136781

A > C

0.10

POLB

MARIE

1.06

0.64

1.73

0.19

0.05

0.78

0.0599

  

0.11

 

BCAC

0.77

0.54

1.09

0.94

0.74

1.20

0.3583

rs3136790

A > C

0.10

POLB

MARIE

1.14

0.70

1.84

0.19

0.05

0.78

0.0474

  

0.12

 

BCAC

0.77

0.54

1.09

0.94

0.74

1.20

0.3452

rs2233921

C > A

0.45

SMUG1

MARIE

1.39

1.04

1.87

0.71

0.38

1.32

0.0072

  

0.49

 

BCAC

0.99

0.81

1.21

0.90

0.77

1.06

0.5524

rs2279399

G > A

0.48

SMUG1

MARIE

0.79

0.59

1.07

0.99

0.54

1.79

0.0941

  

0.44

 

BCAC

1.01

0.82

1.23

1.08

0.92

1.27

0.7312

rs3087404

G > A

0.48

SMUG1

MARIE

0.79

0.59

1.07

1.01

0.55

1.84

0.0874

  

0.45

 

BCAC

1.00

0.82

1.23

1.08

0.92

1.27

0.7083

rs4759344

G > A

0.48

SMUG1

MARIE

0.79

0.59

1.07

0.98

0.54

1.79

0.0952

  

0.45

 

BCAC

1.01

0.82

1.23

1.08

0.92

1.27

0.7390

rs6580978

G > A

0.48

SMUG1

MARIE

0.79

0.59

1.07

0.99

0.54

1.79

0.0941

  

0.45

 

BCAC

1.01

0.82

1.23

1.08

0.92

1.27

0.7345

rs1799782

G > A

0.06

XRCC1

MARIE

1.03

0.59

1.82

0.14

0.02

1.14

0.0965

  

0.06

 

BCAC

1.10

0.73

1.65

1.35

0.97

1.88

0.3074

rs3213255

A > G

0.43

XRCC1

MARIE

0.78

0.57

1.08

1.48

0.82

2.69

0.0708

  

0.42

 

BCAC

1.37

1.13

1.67

0.90

0.76

1.06

0.0010

rs3213356

A > G

0.44

XRCC1

MARIE

0.69

0.50

0.95

1.74

0.95

3.18

0.0106

  

0.44

 

BCAC

1.40

1.15

1.70

0.89

0.75

1.04

0.0005

  1. MAF minor allele frequency, aMARIE: With chemotherapy: 661 (99 events); no chemotherapy: 696 (38 events); BCAC: With chemotherapy: 1,669 (204 events); no chemotherapy: 4,354 (315 events). *P-value for likelihood ratio test (LRT) comparing models with and without the interaction term between SNP and treatment