Table 1 Clinical studies of HIPEC in patients with peritoneal carcinomatosis from colorectal origin

 Verwaal [16, 17]

49^a

MMC 35

-

8

-

29

22.3

>5/7 regions affected; CC

 Elias [22]

523^b

MMC 30–50, CIS 50–100 OX 360–460, IRN 200

31

3.3

-

18

30.1

PCI, CC, nodal status, adjuvant chemotherapy

 Glehen [18]

506^c

MMC, CIS, OX

23

4

10.7

-

19.2

PCI, CC, adjuvant chemotherapy, age <65y

 Hompes [20]

48

OX 460

52

0

21

20

NR

-

 Cavaliere [21]

146

CIS 25, OX 460, MMC 33

27

2.7

-

20

21

CC, liver metastasis

 Quenet [23]

146

OX 300–460, IRN 200

47

4

-

-

41

PCI, nodal status

 Franko [24]

67

MMC 40

-

-

-

-

35

-

 Cashin [25]

69

MMC 30, OX 460, IRN 360

40.6

4.3

-

-

34

-

 Shen [26]

77

MMC 30-40

30

12

-

10

16

CC, bowel obstruction, ascites

 Vaira [27]

40

CIS 100, MMC 16–35, OX 460

55

2.5

23

-

-

-

 Ceelen [28]

166

OX 200–460, MMC 35

35

2.4

-

-

27

CC, neoadjuvant therapy with BEV