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Fig. 5 | BMC Cancer

Fig. 5

From: Intra-tumor heterogeneity in TP53 null High Grade Serous Ovarian Carcinoma progression

Fig. 5

Network analysis of signaling pathways affected by multiple gene mutation. Functional annotation was performed for variants with a possible negative consequence detected by whole-exome sequencing using David protocols (see M&M). Network analysis by Cytoscape tool revealed signaling pathways containing multiple mutated genes. Functional nodes annotated by Biocarta, Gene Ontology, KEGG or Reactome terms are represented in squared nodes. Mutated genes are represented in circles, which colour indicates the samples in which they are mutated (see node fill color mapping)

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