Fig. 1
From: Intra-tumor heterogeneity in TP53 null High Grade Serous Ovarian Carcinoma progression
Clinical case and sample description of an ovarian TP53 null HGSC. a Anatomical location of the primary tumor (blue) and recurrence samples (intra-pelvic samples in green and extra-pelvic samples in red). b Patient’s clinical course. Grey squares indicate periods of treatment between primary tumor diagnosis and relapse. c Representative images of hematoxilin/eosin staining (A) and immunohistochemistries for WT1 (B), Ki-67 (C), PTEN (D) and p53 (E). TP53 mutation detected by Sanger sequencing (F) and its consequence in p53 protein (G)