Fig. 5
Insufficient RFA enhanced the growth of HCC cells in vivo, and sorafenib blocked the process. HepG2 and HepG2-H cells were injected subcutaneously into the upper right flank region of nude mice, treated with or without sorafenib, and tumor volume was measured. (a) Tumor volume was measured with a caliper rule every other day. Data were presented as the mean tumor volumes of mice. (b) Tumor size of the 29th day was displayed. (c) Tumor sections were stained for PCNA, Ki67, MMP-2, MMP-9, E-cadherin and N-cadherin. Representive images of the immunohistochemistry assay were shown (200×)