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Fig. 5 | BMC Cancer

Fig. 5

From: A novel human leiomyoma tissue derived matrix for cell culture studies

Fig. 5

Invasion of oral squamous cell carcinoma and melanoma cells through Myogel-LMA and Matrigel® or Matrigel®-GFR. HSC-3 cells were allowed to invade for three days through Myogel and Matrigel® mixed with agarose, 09-HSC-3 cells have a higher passage number than 13-HSC-3 cells (a). Invasion pattern of HSC-3 cells through different mixtures of Myogel, Matrigel® and LMA (b). Oral squamous cell carcinoma and melanoma cells were allowed to invade for 72 h through Myogel-LMA and through Matrigel®-GFR (c). In a one Transwell® was analyzed for each group except for control at 72 h there were two filters (controls were Transwell®s without coating), six areas per filter were calculated, in c altogether six Transwell®s were analyzed in each group in two independent experiments. As only one filter was analyzed in preliminary experiment with LMA in a, statistical significances were not calculated in that experiment. In c differences were not statistically compared to plain LMA. Horizontal lines indicate mean values, Mann–Whitney U test, ** P < 0.01

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