Table 1 Selected genes predicted to be differentially expressed in a specific astrocytoma grade

H3F3A

1

q42.12

-

PA I

H3 histone, family 3A

MEIS1

2

p14

-

PA I

Meis homeobox 1

NEUROD1

2

q31.3

-

PA I

neuronal differentiation 1

EOMES

3

p24.1

-

PA I

eomesodermin

ZIC1

3

q24

-

PA I

Zic family member 1

ZIC4

3

q24

-

PA I

Zic family member 4

EGR1

5

q31.2

+

PA I

early growth response 1

EN2

7

q36.3

-

PA I

engrailed homeobox 2

EGR3

8

p21.3

+

PA I

early growth response 3

CDKN2B

9

p21.3

+

PA I

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

NTRK2

9

q21.33

+

PA I

neurotrophic tyrosine kinase, receptor, type 2

HIF1AN

10

q24.31

+

PA I

hypoxia inducible factor 1, alpha subunit inhibitor

SUV420H1

11

q13.2

-

PA I

suppressor of variegation 4-20 homolog 1 (Drosophila)

KRAS

12

p12.1

-

PA I

Kirsten rat sarcoma viral oncogene homolog

ZIC2

13

q32.3

-

PA I

Zic family member 2

SUZ12

17

q11.2

-

PA I

SUZ12 polycomb repressive complex 2 subunit

SUV420H2

19

q13.42

-

PA I

suppressor of variegation 4-20 homolog 2 (Drosophila)

OLIG1

21

q22.11

+

PA I

oligodendrocyte transcription factor 1

OLIG2

21

q22.11

+

PA I

oligodendrocyte lineage transcription factor 2

ATRX

X

q21.1

-

PA I

alpha thalassemia/mental retardation syndrome X-linked

ZIC3

X

q26.3

-

PA I

Zic family member 3

FAM110C

2

p25.3

-

AS II

family with sequence similarity 110, member C

HEY2

6

q22.31

+

AS II

hes-related family bHLH transcription factor with YRPW motif 2

NR2E1

6

q21

-

AS II

nuclear receptor subfamily 2, group E, member 1

EYA1

8

q13.3

+

AS II

EYA transcriptional coactivator and phosphatase 1

GAS2

11

p14.3

-

AS II

growth arrest-specific 2

DLL3

19

q13.2

+

AS II

delta-like 3 (Drosophila)

CDH4

20

q13.33

-

AS II

cadherin 4, type 1, R-cadherin (retinal)

SHROOM2

X

p22.2

-

AS II

shroom family member 2

AP1AR

4

q25

-

AS III

adaptor-related protein complex 1 associated regulatory protein

CDC27

17

q21.32

-

AS III

cell division cycle 27

PPM1D

17

q23.2

+

AS III

protein phosphatase, Mg2+/Mn2+ dependent, 1D

ZNF24

18

q12.2

+

AS III

zinc finger protein 24

TXN2

22

q12.3

+

AS III

thioredoxin 2

AKT3

1

q44

-

GBM IV

v-akt murine thymoma viral oncogene homolog 3

MDM4

1

q32.1

+

GBM IV

MDM4, p53 regulator

PDGFRB

5

q32

+

GBM IV

platelet-derived growth factor receptor, beta polypeptide

VEGFA

6

p21.1

+

GBM IV

vascular endothelial growth factor A

EGFR

7

p11.2

+

GBM IV

epidermal growth factor receptor

FGFR1

8

p11.23

+

GBM IV

fibroblast growth factor receptor 1

FGFR2

10

q26.13

-

GBM IV

fibroblast growth factor receptor 2

BIRC3

11

q22.2

+

GBM IV

baculoviral IAP repeat containing 3

ERRB2

14

q24.3

+

GBM IV

nuclear receptor

NTRK3

15

q25.3

-

GBM IV

neurotrophic tyrosine kinase, receptor, type 3

BRCA1

17

q21.31

+

GBM IV

breast cancer 1, early onset

AKT2

19

q13.2

+

GBM IV

v-akt murine thymoma viral oncogene homolog 2

SMARCA4

19

p13.2

+

GBM IV

SWI/SNF related, matrix associated, actin dependent regulator of chromatin